Q: What highway do you take from Seward to drive to Denali?
A: Take the Seward Highway from Seward to Anchorage – it is the only highway out of Seward. Take the Glenn Highway out of Anchorage and then you’ll merge onto the George Parks Highway towards Denali. It may sound like a lot of highways but the Seward Highway and the Glenn Highway are the only highways in and out of Anchorage! You will cover about 250 miles and it will take 7 to 9 hours.